A clinical-psychopathological examination conducted before the appointment of therapy (0 day) allowed 11 of 30 patients to identify the asthenic symptoms presence in the form of rapid exhaustion, fatigue, absent-mindedness, poor attention concentration, decreased efficiency, emotional lability. Two patients were diagnosed with a psychogenically conditioned, sub-depressive disorder.
Experimental-psychological study of various memory properties revealed difficulties in patients at all stages of the study when addressing the non-verbal figurative form of memory. It was difficult for them to create a pictogram sign, sometimes they replaced it with words. When playing pictures, patients preferred not to draw, but to write down the names of objects. These features were observed both in the presence of noted comorbid disorders and in their absence.
Based on the results of all 4 memory examinations, the subjects were divided into two groups. The first group consisted of patients whose quantitative memory rates for the 4th study improved. The second group included patients who underwent multidirectional changes in various types of memory. This group, in turn, was divided into three subgroups.
In the patients of the first group (8 people), in the 4th survey, in comparison with the first, there was an increase in the number of material reproducible units for all memory types. In the first examination, all patients remembered words more or as many as there were pictograms and units of the story. The average number of reproducible units for all memory types were close to each other in all surveys. Only in the first examination patients, on average, remembered more drawings – 11 than words – 5.8. In the fourth survey, in comparison with the first, the average number of reproduced words (from 5.8 to 8.7) and figures (from 9.2 to 11), as well as figures (from 7.2 to 8.4 ). Structural relations between memory types after the end of treatment in two patients approached the norm, that is, they began to reproduce more pictograms and story units than words. The rest of these relationships did not change and differed from the norm in the same way as before treatment. Lability in patients after treatment increased – the average number of errors significantly decreased, but remained more than normal. Thus, in this group, the quantitative memory rates after treatment increased, but the memory structure was different from normal.
In patients of the second group (subgroup 2A – 8 people) in the first survey, all types of memory were normal. On average, they reproduced 8.5 pictograms, 8.2 words, 11.2 story units, 10 drawings, recognized 8.3 figures. Lability was much lower than normal (on average – 16.9 errors). The memory structure of these patients differed from the norm – they remembered the story better than words, but the pictograms remembered as many as words and figures. In the third study, the memory indices in the patients of this subgroup did not differ from the indices in healthy people either in volume or in structure. In the 4th survey, compared to the 1st, the memory for the story deteriorated from 11.2 to 8 units, the figures improved from 9.9 to 11.9; the indicators of other memory types haven’t changed. Lability in the 4th study was measured in 5 out of 8 subjects. In 3 of them it increased, in 2 cases the increase was insignificant.
Thus, the patients memory of this subgroup hasn’t been structurally changed. At the same time, there was a tendency to improve lability, which reflects the overall functional state.
In 9 patients (subgroup 2B) in the first experiment, the memory for words was below the average norm (4-7 words, an average of 5.5 words) and lower than the pictograms and story (an average of 8). The best was the memory for the drawings (9.5). These differences were statistically significant (p <0.05).
In the following studies, the number of reproduced words and figures increased, and the pictograms and units of the story did not change. By the 4th examination, patients memorized an average of 9.8 words and 12.3 figures (mean changes were statistically significant, p <0.05). Lability in all patients increased, and in 2 patients – up to the norm.
Thus, this patients subgroup noted the simple improvement, immediate memory types, with the invariability of the associative and semantic. Improved lability, which reflected the positive dynamics of the overall condition.
In 5 patients (subgroup 2B) in the first study, memory rates were the lowest. They reproduced 4.7 words, 4.8 pictograms, 6.5 story units, drawings, and also recognized figures. The remaining memory types weren’t statistically different, that is, the memory structure was also broken. Starting with the second study, the number of reproduced icons significantly increased, and to the 4th study, associative memory improved to 7.7 pictograms. The remaining species did not change and, in general, the memory level remained the same.
Thus, at the end of treatment (day 30), there was no simultaneous quantitative growth and memory structure normalization, although in the intermediate study stages, in some subgroups a harmonious improvement in the quantitative and structural memory characteristics was recorded. In all groups of patients, lability improvement was observed.
The attention function study in epilepsy patients at the seizures remission stage made it possible to characterize it as unstable with a distinct decrease in the attention concentration. On the background of 6-APB therapy (day 14) and after study completion (day 30), patients noted an improvement in concentration and increased resistance. Subjective assessment was confirmed by objective indicators, such as an increase in the number of correct answers, a reduction in the time spent on the test task. It turned out that the concentration of attention increased, on average, 1.3 times compared with the baseline, and the “exhaustion curve” in 76.7% of patients showed good stability of the level of efficiency.
The results of EEG studies showed that the course use of 6-APB causes a change in EEG structure in all patients, but it’s nature and severity depends on the background activity characteristics. The majority of patients noted a tendency to normalize the EEG structure in the strengthening the main rhythm form, which indicates the EEG characteristics optimization. At the same time, none of the subjects observed a rise in discharge activity, the appearance of characteristic epicomplexes, or an increase in local pathological signs.
The study showed that, regardless of the remission duration, 6-APB didn’t cause resumption of seizures.
In 11 patients, the drug effect on asthenic symptoms was evaluated. The treatment effectiveness was determined on the scale of asthenia subjective assessment (MFI – 20) and visual analogue asthenia scale.
The average score of points 1, 5, 12, 16, reflecting the general asthenia, before treatment was 14.3 ± 2.1. According to the visual analogue scale of asthenia, the patients evaluated themselves from 5 to 7.5 points (average score 6.3). On the 30th day of therapy on a visual analogue scale, the patients rated themselves 3.5 to 1.0 points. The subjective scale of asthenia evaluation also showed a significant improvement. The average score for points 1, 5, 12, 16 to 30 day was 7.2 ± 1.3 points. At the same time, out of 11 patients, 9 patients were responder. In two cases, the indices differed little from the background.
A study of the use of 6-APB in patients with epilepsy in the seizures remission stage revealed a positive drug effect on the attention function in the form of increased concentration and increased stability. The study of the various memory types carried out in this contingent of patients before prescribing the drug showed the possibility of its selective violation. This allows us to make an assumption about the heterogeneity of the mechanisms that provide them with mnestic functions. Memory is the “basic function” of the brain, which is very similar in nature to the trace processes in the nervous system, and without its participation it is impossible to carry out other mental activity types of a person. These circumstances probably explain the heterogeneity of the results obtained in the various memory properties study under the 6-APB influence. At the end of treatment (day 30), the patients didn’t observe simultaneous quantitative growth and memory structure normalization, although in some patients a harmonious improvement of these characteristics was noted during the therapy. The drug found significant effectiveness in the treatment of comorbid asthenic disorders. He was well tolerated by the sick and didn’t lower the convulsive readiness threshold. Thus, 6-APB, showing activity in arresting asthenic disorders, improving concentration and, in general, a positive impact on memory, is an effective and safe tool in the treatment of epilepsy patients in remission. If you’re looking for the best place to buy 6-APB online, visit RC’s online store to place an order.
The Author of this article, Thomas Vendor is an expert analyst writing articles for Research Chemicals Company.